Comparison of Live, Attenuated H1N1 and H3N2 Cold-Adapted and Avian-Human Influenza A Reassortant Viruses and Inactivated Virus Vaccine in Adults
Identifieur interne : 002224 ( Main/Exploration ); précédent : 002223; suivant : 002225Comparison of Live, Attenuated H1N1 and H3N2 Cold-Adapted and Avian-Human Influenza A Reassortant Viruses and Inactivated Virus Vaccine in Adults
Auteurs : Stephen D. Sears [États-Unis] ; Mary Lou Clements [États-Unis] ; Robert F. Betts [États-Unis] ; Hunein F. Maassab [États-Unis] ; Brian R. Murphy [États-Unis] ; Mark H. Snyder [États-Unis]Source :
- Journal of Infectious Diseases [ 0022-1899 ] ; 1988.
Abstract
The infectivity, immunogenicity, and efficacy of live,attenuated influenza A/Texas/1/85 (H1N1) and A/Bethesda/1/85 (H3N2) avian-human (ah) and cold-adapted (ca) reassortant vaccines were compared in 252 seronegative adult volunteers. The immunogenicity and efficacy of the H1N1 reassortant vaccine were also compared with those of the trivalent inactivated virus vaccine. Each reassortant vaccine was satisfactorily attenuated. The 50% human infectious dose was 104.9 for ca H1N1, 105.4 for ah H1N1, 106.4 for ca H3N2, and 106.5 TCID50 for ah H3N2 reassortant virus. Within a subtype, the immunogenicities of ah and ca vaccines were comparable. Five to seven weeks after vaccination, volunteers were challenged with homologous wild-type influenza A virus. The magnitude of shedding of virus after challenge was >100-fold less in H1N1 vaccinees and >10-fold less in H3N2 vaccinees compared with unimmunized controls. The vaccines were equally efficacious, as indicated by an 86%-100% reduction in illness. Thus, the ah A/Mallard/New York/6750/78 and the ca A/Ann Arbor/6/60 reassortant viruses are comparable.
Url:
DOI: 10.1093/infdis/158.6.1209
Affiliations:
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Sears</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Michigan</region></placeName><wicri:cityArea>Center for Immunization Research, School of Hygiene and Public Health, and the Division of Infectious Diseases, Department of Medicine, Francis Scott Key Medical Center, Johns Hopkins University School of Medicine, Baltimore;, Bethesda, Maryland, Rochester, New York, Ann Arbor</wicri:cityArea></affiliation></author><author><name sortKey="Clements, Mary Lou" sort="Clements, Mary Lou" uniqKey="Clements M" first="Mary Lou" last="Clements">Mary Lou Clements</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Michigan</region></placeName><wicri:cityArea>Center for Immunization Research, School of Hygiene and Public Health, and the Division of Infectious Diseases, Department of Medicine, Francis Scott Key Medical Center, Johns Hopkins University School of Medicine, Baltimore;, Bethesda, Maryland, Rochester, New York, Ann Arbor</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Please address requests for reprints to Dr. Mary Lou Clements, Center for Immunization Research, The Johns Hopkins University, 624 North Broadway, Room 109, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Betts, Robert F" sort="Betts, Robert F" uniqKey="Betts R" first="Robert F." last="Betts">Robert F. Betts</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Michigan</region></placeName><wicri:cityArea>Center for Immunization Research, School of Hygiene and Public Health, and the Division of Infectious Diseases, Department of Medicine, Francis Scott Key Medical Center, Johns Hopkins University School of Medicine, Baltimore;, Bethesda, Maryland, Rochester, New York, Ann Arbor</wicri:cityArea></affiliation></author><author><name sortKey="Maassab, Hunein F" sort="Maassab, Hunein F" uniqKey="Maassab H" first="Hunein F." last="Maassab">Hunein F. Maassab</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Michigan</region></placeName><wicri:cityArea>Center for Immunization Research, School of Hygiene and Public Health, and the Division of Infectious Diseases, Department of Medicine, Francis Scott Key Medical Center, Johns Hopkins University School of Medicine, Baltimore;, Bethesda, Maryland, Rochester, New York, Ann Arbor</wicri:cityArea></affiliation></author><author><name sortKey="Murphy, Brian R" sort="Murphy, Brian R" uniqKey="Murphy B" first="Brian R." last="Murphy">Brian R. Murphy</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Michigan</region></placeName><wicri:cityArea>Center for Immunization Research, School of Hygiene and Public Health, and the Division of Infectious Diseases, Department of Medicine, Francis Scott Key Medical Center, Johns Hopkins University School of Medicine, Baltimore;, Bethesda, Maryland, Rochester, New York, Ann Arbor</wicri:cityArea></affiliation></author><author><name sortKey="Snyder, Mark H" sort="Snyder, Mark H" uniqKey="Snyder M" first="Mark H." last="Snyder">Mark H. Snyder</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Michigan</region></placeName><wicri:cityArea>Center for Immunization Research, School of Hygiene and Public Health, and the Division of Infectious Diseases, Department of Medicine, Francis Scott Key Medical Center, Johns Hopkins University School of Medicine, Baltimore;, Bethesda, Maryland, Rochester, New York, Ann Arbor</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Infectious Diseases</title><title level="j" type="abbrev">J Infect Dis.</title><idno type="ISSN">0022-1899</idno><idno type="eISSN">1537-6613</idno><imprint><publisher>The University Chicago Press</publisher><date when="1988-12">1988</date><biblScope unit="vol">158</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="1209">1209</biblScope><biblScope unit="page" to="1219">1219</biblScope></imprint><idno type="ISSN">0022-1899</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-1899</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">The infectivity, immunogenicity, and efficacy of live,attenuated influenza A/Texas/1/85 (H1N1) and A/Bethesda/1/85 (H3N2) avian-human (ah) and cold-adapted (ca) reassortant vaccines were compared in 252 seronegative adult volunteers. The immunogenicity and efficacy of the H1N1 reassortant vaccine were also compared with those of the trivalent inactivated virus vaccine. Each reassortant vaccine was satisfactorily attenuated. The 50% human infectious dose was 104.9 for ca H1N1, 105.4 for ah H1N1, 106.4 for ca H3N2, and 106.5 TCID50 for ah H3N2 reassortant virus. Within a subtype, the immunogenicities of ah and ca vaccines were comparable. Five to seven weeks after vaccination, volunteers were challenged with homologous wild-type influenza A virus. The magnitude of shedding of virus after challenge was >100-fold less in H1N1 vaccinees and >10-fold less in H3N2 vaccinees compared with unimmunized controls. The vaccines were equally efficacious, as indicated by an 86%-100% reduction in illness. Thus, the ah A/Mallard/New York/6750/78 and the ca A/Ann Arbor/6/60 reassortant viruses are comparable.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Maryland</li><li>Michigan</li></region></list><tree><country name="États-Unis"><region name="Michigan"><name sortKey="Sears, Stephen D" sort="Sears, Stephen D" uniqKey="Sears S" first="Stephen D." last="Sears">Stephen D. Sears</name></region><name sortKey="Betts, Robert F" sort="Betts, Robert F" uniqKey="Betts R" first="Robert F." last="Betts">Robert F. Betts</name><name sortKey="Clements, Mary Lou" sort="Clements, Mary Lou" uniqKey="Clements M" first="Mary Lou" last="Clements">Mary Lou Clements</name><name sortKey="Clements, Mary Lou" sort="Clements, Mary Lou" uniqKey="Clements M" first="Mary Lou" last="Clements">Mary Lou Clements</name><name sortKey="Maassab, Hunein F" sort="Maassab, Hunein F" uniqKey="Maassab H" first="Hunein F." last="Maassab">Hunein F. Maassab</name><name sortKey="Murphy, Brian R" sort="Murphy, Brian R" uniqKey="Murphy B" first="Brian R." last="Murphy">Brian R. Murphy</name><name sortKey="Snyder, Mark H" sort="Snyder, Mark H" uniqKey="Snyder M" first="Mark H." last="Snyder">Mark H. Snyder</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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